Rather than trod down the well-worn path of .243 Winnie for a varmint/deer cartridge, after reading a bunch and messing around with ballistics software a bit, I concluded that the .250 Savage is pretty close to ideal for hunters east of the Mississippi. New brass is readily available, bullet support is excellent including premiums, no handloading peculiarities (given a fast enough twist rate for 120 grainers) according to the writers. Lots of varmint bullets at 75 grains, lots of deer bullets from 100-120 grains.
Of course, NEF doesn't chamber for it, and I'm guessing that rechambering a .25-06 barrel down to the little Savage case wouldn't leave much barrel! So the next step would be to get a donor barrel, rebore to .257", then rechamber for the Savage. It looks to me like the .223 would be the way to go; plenty of bore "meat" for drilling and rifling, and if I'm reading the case dimension drawings correctly the breech end wouldn't have to be turned off, simply run the breech over the reamer.
Has anyone done this? Any reason to not do this?