I agree with Booth , all but 2 of my Handi's like mid pressure loads to shoot best , the exceptions are the 22 Hornet that likes low pressure rounds and the 22/250 that has to be hotrod'ed .
The chamber on the 250 is tight enough that I can just Neck Size and still get desent case life , while the Hornet will only last about 3 loadings before the case's are junk , no matter how I size them .
I have not found any real advantage to one type over the other as far as sizing goes , except for the 250 , so I just FL size to avoid any issue's .
stimpy