This has been an interesting discussion/topic. I might as well ask a few questions too. First, those that shoot cast bullets, what are you using for clean up? I absolutley hate cleaning lead from a barrel, finding Kroil floats it pretty good, and reading that Bronze Wool is pretty good stuff for clean up. Just curious on this.
As to cast bullets versus jacketed. I'm not sure that you can say that cast will be better than jacketed in all instances. Namely that the construcion of both (as has been discussed at least with lead) varies significantly. In addition, while the wider meplat does have the potential to do more damage (depending on bullet designs) the difference between some cast and jacketed meplats are so small, as to be in the real world, mostly a wash.
I see a lot of folks recommending cast bullets. But there are some good jacketed bullets out there too. In addition, I've seen folks recommend using cast bullets, and in the next line discourage the use of jacketed "because they won't open up, just punch right through." For larger caliber handgun rounds I thought that was the point of using cast. Of course, it certainly depends on what you are shooting.
For instance, when I got my .44 Magnum Ruger Vaquero Bisley, I settled on the 300 grain Speer bullet, over a load of IMR 4227 that chronos at 1050 fps. This is not a smoking round by any means, but I have found it penetrates well in my "stump" tests, I shoot it very well and accurately and have no qualms wallking about planning on shooting a bear or elk with this load at a max distance of 50 yards. I have taken a whitetail with it, and found that it performed much like a cast, boring right through the deer. As a matter of fact, when I hunt the midwest, I actually switched to a 300 grain XTP because of this. Where I hunt whitetails, I decided some expansion would not be a bad thing. This particular bullet is very hard, and I fully expect complete penetration of elk out to my limit of 50 yards broadside. In that 300 Speer, I feel I have the best of both worlds, little problems with leading and the convenience of a jacketed bullet, the hardness (or nearly that of) a cast.
As to hunting with handguns and taking other than broadside or slight quartering shots, it's users choice. To me the argument of "if you wound one you want to shoot stem to stern" doesn't hold water. Wait for the shot presentation you want, if you don't get it, that's why it's called hunting, not critter killing. However, if you do wound one, as happens on occasion, fill 'em full of lead and put them down, if you see hide, shoot it. You've already miffed the shot if that happens and you owe it to the animal to end the suffering as soon as possible. I'm not sure that requires you to always shoot a bullet that will pass stem to stern unscathed, but that's just my opinion.