To answer your question, yes it can be done very easily, BUT, why bother with the .22-250 AI. You will not get enough extra case capisity to make it worth buying custom dies. If your after a hot rod why not go with a .22 - 243 or a .22 - 6mm. I just had a .22 - 6mm built and I`m pushing an 80 gr. bullet to alittle over 3,500 fps. right now, I`m just getting started seeing what it will do. I have a 1 in 8 twist in it for the 80 gr bullets and with you barrel you`ll probibly be limited to 69 gr. bullets, maybe 75`s.