The .350 Rem Mag is a heavy hitting cartridge, both ends. I own two guns that shoot this cartridge, a Remington 600, and a Ruger M-77. I love the looks of the Remington, but the magazine is too short to accept anything but 200gr bullets. I like to load the .225gr bullet and the Ruger handles them well. I can load the 250s and feed them individually, they are just a little too long for the Ruger magazine. They work well on bears from a stand. Range is not that great, so I only use them when hunting over bait.
I own one .35 Remington, it stays down in Tennessee with my only 30-30, for use on Whitetails from a treestand. Where ranges are 40 yards or less. I don't think it is of much use here in Alaska.