With the exception of "head shots right between the eyes," hogs are tough to put down and generally require bigger cartridges and heavier bullets.
I once had my brother use my 7mm Rem Mag, with plain jane 150 grain Winchetser Power Points, on a 250 lb hog. My brother, who is not an avid huner, aimed right at the shoulder, thinking that it would anchor the hog. Bad idea. At the shot, the hog dropped, made a few circles, got up, and ran off....never to be found. At the place of impact, there was chucks of bone and blood. However, after about 10 yards or so, there was no blood trail whatsoever. My brother should have used what I told him to use...a 160 Nosler Partition or Barnes X. Even then, I don't advocate shooting pigs on their shoulder because it is like a steel plate.
Don't laugh, but do you know what my favorite hog rifle is....at least for large hogs?....A .375 H&H Mag with 300 grain Nosler Partitions. Do you need such a big gun? No. Is it added insurance for big pigs...heck yes!
Another fine choice is a .30-06 with 180 grain Barnes X. These bullets really penetrate!
Zachary