I used to have the 6.5" blackhawk last year for hunting, and used a 210gr. lee tumble lube bullet made of wheel weights, regular cci primer, and a 1cc dipper full of unique(9.2gr.). It made for a nice practice load that you could shoot all day long. For deer I loaded up a 210gr. Speer GDHP, regular cci primer,and 19 gr. of 2400 powder. It penetrated roughly 30" through a yearling deer at 40yds. last year. Hope this helps.
-Amos