My Sierra data would have one start the 240 gr JHC @ 14.2gr bluedot for 1,000fps & ends @ 16.9gr
For 1,250fps (Accuracy load is listed as 15.3gr & 1,100fps)
They have their 300gr JSP starting @ 11.5gr for 800fps & ending @ 14.0gr for 1,000fps
240gr OAL=1.600
300gr OAL=1.650
CCI 350 Primers Are Used With Both Bullet Weights
Note: These Loads Are For Ruger, Colt Anaconda, Dan Wesson, & Freedom Arms
I know you were wanting data for a 250gr bullet but this should give you something to go on.