I have had good luck with 18.5 grs. of H-110 with a 315 gr, gas check, Winchester brass, CCI mag primers. In a 10" Contender, they ran 1,350 fps., and shot well under 1" at 50 yds. 18.0 grains H-110 with the same bullet runs around 1,100 fps. in a 4" S&W.