I load just a limited few 45 Colts for a friend of mine. I use 9 grains of Unique with a 200g JHP, which is a fairly light load, but stouter than any Cowboy loads I've seen. Even as low as 8 grains we never had ignition problems with standard primers.
I haven't tried Trail Boss in the 45, but it's the best thing I've ever seen in light 32 magnum loads. With a 97g-98g cast SWC, 2.5g gives me about 750 fps with very low noise, and hardly any recoil. I can't help but think if you're looking for a similar 45 Colt load, Trail Boss would be very hard to beat. It's very clean burning, easy to ignite, meters very consistently, and fills the cases better than any of the other fast burners.