Inadequate information provided to give a response. Need to know distance, gun/load used and angle.
I respectfully think that this is irrevelent as one could be using a .22 shooting at a Squirrel that is 125yds away from a 300ft elevation...Or one could be shooting at a dall ram at 200yds from a 600ft elevation. My point being that we are matching the caliber to the game within the respective ranges of the said caliber. Hail Mary, or Billy Dixon shots are not to be counted. In other words, the bullet will not cross over the line of sight by more than three inches. The extended range is dictated by the caliber, the bullet drop is adhered to keeping the diameter of the vitals of the game hunted in mind.
Now For The Question... If you shoot a bullet straight up, Theoretically it will run out of power and fall straight back down into the bore.
If you shoot a bullet straight down, it will go just there.
If you shoot on the Horizontal, you will get a horrible curve as compared to straight up or straight down. At this point, it doesnt matter if you raise or lower the muzzle from the horizontal. The lines are going to get flatter & flatter untill you are once again shooting straight up or straight down.
This happens because gravity is pulling on a smaller part of the bullet when shooting uphill or downhill.
I love my sparkling clarity so I will include a final answer just in case. When Shooting Uphill Or Downhill The Bullet Will Strike High. I recon that an /06 with a 180gr bullet shot over a 200yd range at a 45degree angle is going to be around 6" high.