There is something to be said about a large bullet with a large flat tip. They seem to kill beyond energy figures. There has been every North American game animal taken with a 44 magnum with heavy cast bullets including the big brown bears of Alaska. They seem to pole axe any thing that they hit. A 45 Colt loaded up stiffly would do a good job too. Not to mention the 45-70 or a 444 Marlin with heavy cast bullets. The cast bullets do not upset very much if any at all. With all but the largest game, they just tear a big wound channel and bust out the other side dropping them in their tracks. Of course you are not going to this at 300 yards because of the bullet drop, not because there is not enough killing power. Even though they are not going to get the shock power of a high velocity bullet, they seem to knock 'em over with ease. Like was said above, you are going to feel a bowling ball at a third of the velocity a lot more than baseball. We hunt with shot gun slugs around here a lot. Any deer hit in the vitals is dead. Slugs are soft, I saw one that hit a deer in the neck near the base, bang flop. The recovered slug flatten out to about the size of a silver dollar. They will still run with a "gut shot". I do not care what you shoot, if it is poorly placed it may kill eventually, but it will take a lot of time, more than likely resulting in a lost dead animal. A hard cast bullet penetrates deep. If the above mentioned deer was hit the same with a hard cast bullet it would have went right through smashing the neck bone in the process, still dead of course. What were we talking about?