For quite a few years my carry gun was also my woods walking gun. A .45 acp loaded, warm, with Verl's 225g LFN slug. I was not planning to hunt with it, it was only carried for Orks or varmints. Either in the night or those which might get ornery during daylight.
I talked a bit to Verl before buying the mold. He felt (as I recall, remember this was at least 7 or 8 years ago) that that bullet loaded warm (900+fps) would probably let air in on both sides of a normal sized black bear (broadside shot) or would probably break leg bones.
You have to make a couple of assumptions. One, you are alert enough (or lucky enough) to spot the trouble before it starts. Or two, the ork or varmint blows the first attack and gives you time to defend yourself. Having made those two assumptions and living and camping in California where the last Griz. bought it 70+ years ago, I figured I was well armed against Orks, dogs, Kitty's or black bear. Orks and dogs run in packs. Depending on which mag I was using I had either 8 or 9 rounds on tap without reloading. That's better then 6! Kitty's don't run in packs and don't have the reputation for being that hard to kill. Black bears don't run in packs either, but do have a reputation for being hard to kill. Now I know that nothing is certain except death and taxes but I felt pretty dam certain that if I let enough air in and blood out of a black bear with the hard cast LFN's it was going to get sick and die. Would it maul me first? Maybe, maybe not. Hell it might be mauling me before I even got a shot off. In any case I felt at ease packing the .45acp. A properly loaded 10mm has even more power and penetration. The only reason I did not carry one of them was I was too broke (or cheap, the matter is open to debate) to buy one. That and I already had dies, molds, bullets and over 1000rounds of brass for the .45acp.
Nowadays I may carry a RBH 5.5" in .45LC or a S&W Mountain Gun in .44Mag when I am in the woods. But to tell you the truth I don't feel any more or less secure when I carry them then I do when I pack the Government model.
--
Grendel
If you love wealth better than liberty, the tranquility of servitude
than the animating contest of freedom - go from us in peace. We ask not
your counsel or arms. Crouch down and lick the hands which feed you.
May your chains sit lightly upon you, and may posterity forget that you
were our countrymen!
Samuel Adams