As has been said, the 45 acp is not the best choice for the job.
I think that in this case Nonya is correct - while the 45 acp may break through dead animal bones it may not perform so well on a live animal.
And no 'testing' is in any way a waste of time or a worthless endeavor. Testing, so to speak, is how we got to where we are now with guns and bullets, whether it was old Elmer Keith experimenting with his bullet designs or (the almost equally old) John Taffin, or others, testing the penetrability of other cartridges or designs.
It has been said that a 44 magnum with a 255 gn cast swc slug at betwixt 950-1000'/sec is all that is needed for whitetail and other game. That leaves to reason that the 45 acp with a 230 gn cast swc at 950'/sec should be able to perform the same. Maybe. The results for both may lay in the bullet design; the swc design which has the tendency to cut/punch on through without being thrown off course by heavy bone structures or heavy tissue whereas the 'rounder-nosed' design is used to enhance semi-auto feeding and fucntional reliability but does little to enhance penetration on game animals.
At this time there are only two semi-wadcutter bullets designed for the 45 acp - the old Lyman 452423 and the newer MagTech 230 gn fmj-swc. There are those designed for the 45 Colt that can be made to work in the acp but they run a somewhat heavier, about 10% or so. I'm in the process of testing the MagTech bullet - first tests were pretty positive in terms of feeding and accuracy; next round of tests will involve penetrability.
I'll keep you posted. Mikey.