450/400 NE is top of my list as well, probably in the No 1. 404 Jeff was originally loaded to match this round although it is hotter now. Once considered the best "all arounder" in Africa, before the 375 H&H. Will give tremendous penetration and will probably recoil less than a 375 No 1., low pressure in that big case. Gregor Woods, Boddington and other scribes sing the praises of this cartridge. Ruger should be praised for bringing this classic back.