Just something else to ponder, do you really want to carry hand-loads in a defensive handgun?
I mean, god forbid you need to use it, but to add that burden to your eminent court case is more chances than I would be willing to take.
There are MANY great factory loads out there, I would advise you buy a couple and go to the range. Whatever gives you 100% reliability and adequate accuracy is a good choice.
CW