Bullets available for the 243 years ago VS those available now are like night and day. The .243 once had the reputation (earned) for wounding because bullets simply blew up with not enough penetration. You use a Speer Grand Slam, Nosler Partition, or any of the newer bonded core bullets, hit a deer behind the shoulder out to 300 yards, its going down. Furthest I've seen one run is 100 yards, this from over 20 I've used the .243 to take. I actually missed my aiming point at 300 yards a couple years back, the 100 gr. Nosler Partition bullet broke both shoulders on a decent 8 point buck.