I have shot Coyotes with many calibers. Most have been shot while deer hunting, but a couple while chuck hunting and even one when Turkey hunting. Around here, the season on yotes is closed during turkey season. But when one made a beeline for me after a few clucks and purs, he got a face full of 3 1/2" #5's at about 5 yards. I am just VERY LUCKY he came in from my front where I at least had a chance to see him coming!! A couple of friends have had identical "attacks".
Any how, back to the comment... The hornet will kill them if you can hit them, they just may run off. I think of varmints differently than I do game animals. I don't really shoot that many and done eat any of them so I don't means I don't have to bury them.
Since the introduction of the 17HMR its been my #1 coyote caliber. But remember the ranges I shoot them at here are much closer than other places. 100yrds is a long poke!! The 17 has dropped every one nearly in its tracks. Head shots are the norm, with many going all the way thru. Some of the really close ones don't exit. Let me tell you, seeing a coyote spin around at 1000mph and stop almost as fast after a head shot is a sight to behold. Not to mention the noises they sometimes make.
If you looking for violent expansion and hammer of Thor type kills. You want a speedy bullet. I say stay light and keep the shots as close as possible.
CW