As long as there in ZERO gap between the bullet and the powder, or you can have the powder, with a card wad on top, with the bullet seated on top of the card wad, but NO spaces in the case. This allows BP and BP substitutes to explode, rather than a controlled burn, and YES it could destroy that 50,000 PSI weapon in these circumstances.
If you load the bullet forward in the case, it still has to be seated against the powder.
If all you want is reduced loads, the go with the info you're getting from the other members here, but fillers do not work the same for BP as they do for smokeless. In a 50% smokeless load, the filler serves to keep the powder against the primer for more even ignition, but the burn rates are not altered, even if no filler is used. Not so with black powder, if there is open space, it can actually alter the burn rate, making it an explosive, not what you want in the chamber.
Load it with BP or Pyrodex, and a card, between the gas check and powder, seated firmly against each other, and you'll most likely be pushing that 440gr bullet about 1500fps. It should be a pleasant load compared to the 500 factory stuff.