I put a bushnell 2-6x32 trophy on my Ruger Bisley Blackhawk hunter 44 mag because I have been intrigued by trying one for a while...
tried open sights and various red dots and will keep my S&W 686 357 mag open sights for the times I am hunting with a rifle but want a pistol just in case something close comes in.. when I am dedicated pistol hunting (especially from a stand) I think I will be using this setup
using inexpensive Magtech 240g JSPs I zeroed in at 75 yards and then shot an honest 2.5" group extreme spread with 6 shots
a few of the shots were almost touching
that should work on deer or hogs

pretty cool