As far as I can tell the largest animal is an Elephant ,and there have been countless taken with .458's including the more powerful .458 Lott. I have only shot an Elk with my CZ550 .458 Lott at 60 or 70 yards and it worked but the recoil was insane ,it is now a safe queen. have no fear a .458 Lott will do the job if you do yours. If I were you I would get a better set of iron sights and a brake to reduce recoil . plenty of big dangerous game has been taken with lesser calibers including elephants. also I would shoot at least a box of ammo through it B4 you go on your hunt .