If you're wanting to have revolver ammo that HOT, you might re-consider what you want to do. A Black Hawk with adjustable sights would be a good idea with the high performance loads you want.
Either model VAQUERO, or any fixed sight gun, is somewhat limited. They are "close enough for government work," and can be somewhat aggravating to get to shoot point-of-aim and point-of-impact. I have the Original Size VAQUEROS in 357 and 44...and shoot them a lot...but I don't consider them the appropriate model for high performance ammo. They're safe and relatively comfortable to shoot with the hot stuff. All of mine are BISLEYS or have HUNTER/DRAGOON grip frames. But they don't deliver enough accuracy with their fixed sights.