Thoughts:
#1). Mr. Ackley did not recommend, generally, the .30/'06 improved. Too little gain. He did relent for use with heaviest bullets, 180 up. This is exactly contrary to what you propose.
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#2). '06 was a military project. (Surprise.) It was orginally a 220 grain round nosed bullet with best powder technology at the time, thus the 1 in 10 twist. Cartridge called .30/'03. Powder improvement (borrowed from Germany???) allowed a new, lighter, pointed bullet at much higher velocity. Revised the .30/'06. 1 in 10 was retained. I have always noted that the .308, aka 7.62x51mm NATO, was always twisted 1 in 12 from day one.
And its bullet weight limit was 200 grains per factory. But then they sell to a mass market.
#2). You mention the VLD concept bullets. It is all a "balancing act." As you go lighter, you must also go "lighter." Making this lighter mass into a long ballistic shape... you lose more than you gain at some point. You speak of the lighter bullets ONLY. VLD advice might not be ideal for your use.
#3). Savage went 1 in 14 with the original .250 savage to get the 3000 feet per second in the name. .250/3000. 87 grain bullet too. Most took a 100 grain bullet for game. Round nosed. I suspect you could be happy with a 1 in 14 but this is a decision to consider carefully. Twist does use up some bullet energy. Mr. Ackley said 1/3. I questioned that and he most graciously said he would check and got back to me with the wisdom of some math whizzzz. Correct. 1/3. Obviously 1 in 14 uses less than 1 in 12, etc. luck