I would say that with a two handed grip it wouldn't be that big a deal. I know several shooters prefer using index finger to release mag, the release is reversable if you prefer though. The decocker will require you to use other hand though. I'm pretty sure it is available in DA only, so decocking would not be an issue. If DAK is available in that model it would be preferable to the DA only. DAK gives a more Glock like trigger action, not the same but best I can describe here. You lefty's seem to figure things out, and I'm sure that you'll make it work if you want to. (my oldest is a south paw)