What type of ML is that you are shooting? I just don't see MOA at 400 yards as it is hard enough at 200-250.
TC Omega (thumbhole laminate) with tactical scope (I dial for EXACT range from laser rangefinder, I do NOT hold over). I did refer to MOA and not 1-inch groups, as I average around 4 inches or so at 400 if the wind is not kicking up across the range. Sub-4 is probably consistent and the best ever was around 2 inches but that was luck.
I use a 200gr Shockwave and 110gr loose FFg 777 powder. I accurized the gun by installing aluminum pillars, floating the barrel, and bedding the action. This was required because the point of impact shifted with action screw tightness before I did it.
Usually, if a gun will shoot MOA at 100 yds you can get that or close to it at 300-400 if you are using a load that stays supersonic at the target. But while the gun may do it it requires more skill on the part of the shooter.
I burned through 5-6 lbs of powder and hundreds of shots during load development for this gun, and once I found the perfect load I have not changed a thing in 4 years. I do not try the latest bullet or the latest powder -- I stick with what is worked and proven. I have probably a thousand shots or more with this exact load through this gun in that time -- I think I shot close to 200 rounds just tuning a new scope and calculating long range drops last summer (I have a 400yd backyard range).
Even with all that effort most of the deer this gun has taken, probably 80% of them, have been 120 yds or less (if I can get closer I do). Another 10% fall from 120-180 yds. I think I have only shots 4 over 180 yds at game -- 205, 209, 233, and 338. Wind is a huge factor past 200 so I usually pass on them unless it is more or less calm (which is not often the case).