Yes, I have done the 16 grains of 2400 and it works great for target shooting. Ed recommended something a bit more powerful for hunting. I have used it a lot for cast bullet shooting. Ed has another load he recommends for reduced jacketed bullets.
I have also done the H4895 reduced load for cast bullet shooting in a number of calibers. What the factory advised me, when I emailed them was take their recommended full power load for a given caliber and bullet weight and then cut it no less than in half and it will be fine for target shooting. Never had any ignition problems and never needed any filler.
The H-4895 youth hunting load is 60%, if I remember correctly, but using a jacketed bullet designed to expand at a much lower velocity, usually a bullet designed for use in a Thompson Contender pistol.
So the recommendation sort of has to do with whether you target shoot with cast lead bullets or want jacketed bullets to use for hunting.