As Savage say's, it is handy to have set-ups for the different calibers you are loading. I have a Dillon 550 set up for large primers, but I only us it for 45ACP, as I use my RCBS Rock Chucker single stage & a Lyman All-American turret press for loading .308 ammo. I do that because I only use the .308 for long range target stuff, & don't require fast production. I have another Dillon 550 set up for small primers. All I have to do is clear the small rifle or pistol primers, Fill the tube with the kind I need & change the die head. This only takes a few minuets. The dies rarely need adjusted (unless I am changing the type of bullit I am using, & of course the powder dispenser needs adjusted for different loads) With this setup I load .223, 38/357, 38 Super, and 9mm.