Yes, the Marlin will feed them just fine. HOWEVER, the Marlin chamber is nearly the same diameter as the 45 Colt's rim. Using normal .452" - .454" bullets prevents the case from sealing the chamber and fills the action with powder fouling. For my solution, I had to go to a roundabout way of making ammo for mine. I only size enough of the case to hold the bullet. I made up a .457" expander plug for my second die. I use .458" bullets, either a #454424 mold I have or #458191 (I think that's the number - 290gr. 45-70 bullet), seat in one step with the seat die backed way off and taper crimp in another step. Even with those big bullets the cases still look like big 44-40s with a slight bottleneck. After all that, my 1894 is an absolute tack driver with either smokeless or black powder, and feeds super slick. I really like it, but they could have chambered it properly and saved all the hassle. It goes without saying that ammunition for this rifle is not at all compatable with 45 Colt revolvers or any other gun.