I owned two Pythons on two separate occasions. I bought both for the looks and the idea they were Colts.
As a Police instructor I have fired thousands of rounds sometimes per week, but admit I was never really into shooting targets.
I went to an invitation only school for instructors only at Tarrant County S.O.'s range for two weeks back in the mid-70s, and at the time I carried one of these Pythons. There were two officers there carrying a Python. Myself and another. We got a lot of ribbing from all the others as they carried Smiths. Everything from 38 special to 44 mag.
We had to shoot at least two qualifying matches a day on a combat course and many times shot five. After 4 days blisters were coming up on the web of hands, and the trigger fingers but, we taped and kept shooting.
I found out two things about the Python vs the Smith in that two weeks. The Python has a longer trigger pull and the weight STACKS regardless of how smooth it is, and using speed loaders you could not get thru a box of 158 grain jacketed 357 mags in a speed "demo" before heat expansion locked the cylinder. Real world on the speed demo? NO, but the point was made. The instructor, an FBI agent thought it was funny. It was a set up on the other guy carrying the Python.
I never shot less than 96 out of 100 score for the entire two weeks, but a big guy from Tyler Texas never shot less than a perfect score and he was using a Model 29 4" in 44 Mag. Back then we were taught to shoot from anchor points on the body such as the hip. He wore two t-shirts, because by the end of the day, the gas coming out between the cylinder face and the forcing cone would burn thru the first shirt, and burn his stomach just above his gun belt.
Which gun won on accuracy? Probably neither. Back then, I was a helluva shot, but that guy beat me, with a gun that was making him pay with every shot. The Python was making me pay with that longer trigger pull, and it was glassy smooth.
I went back to the Model 19 Smith after that schoool, and later to a 1911. Of course this week I sold a long carried 1911, and bought a Glock 21. That is another story.
I know nothing about your handgun brand, but I wouldn't fear the Python accuracy. Without the Ransom rest, all handguns will shoot only as close as the shooter is capable of shooting.