I find that Pyrodex in cartridges works better the more you compress it up until you start to bulge the case. I also learned that the expander plug in most pistol die sets works pretty good at compressing powder. So now, I first size the case, expand and bell it like normal, fill the case with powder, set the expander to go in as far as the bullet does to compress the charge, and seat the bullet.
The handi rifle is one of the few firearms I will use Pyrodex in, because it cleans up so easily. That stuff is wicked corrosive, so take care to clean your guns and cases well after use. Also try not to inhale the smoke, it's not terribly healthy. If you can get real black powder, I will always recommend it over Pyrodex.