There is not just one powder that does it all - well. You are talking light 44 Special loads to heavy 44 Mag loads with a case capacity to also cover the 45 Colt. For light loads I think that Unique can't be beat in your cases, and it will work for heavier loads, but it will not get you the best velocity with out pressures getting up there, but it can be used, you will just get a couple of hundred fps less out of your top loads. I use Unique for my light loads and W296/H110 for my heavy loads. You can not use W296/H110 for light loads. Good Luck and Good Shooting.