It has been my experience that when used on deer size game the 300hp is all you need.
It will give complete pass through, which at least in mine and my buddies cases it didn't matter as every deer ever shot with them except three dropped in their tracks.
Behind the shoulder, in the shoulder (tears up some meat), neck, head it didn't matter, they went down.
We are meat hunters only.
I am sure that the 405gr lead as well as others will do about the same but the 300s will give a flatter trajectory.
Just my 2 cents.
LONGTOM