You deserve a better answer.
Whether Encore or Omega, the barrel is not tapered. A .45 caliber gun gets you a smaller hole in the same pipe. That means more weight, and more nose-heaviness. It also give you less barrel volume / combustion space.
With a .50 caliber, you have a .50 with conicals, or a .45 / .44 / .40 / .357 gun with sabots. The fifty is easily a .40 caliber rifle, but the .45 can never be a .50 cal for larger game. And, those .40 cal Dead Centers shoot great out of the .50 caliber Thompsons.