Been carrying a 30-06 Handi since 1995. I had it sighted in to be dead on at 300 yards, and can consistantly hit a clay target at that range. I had a Shepard scope mounted on it for long range work. I shot only my hand loads, and loaded Speer 125gr TNTs, Sierria 165gr BTs, and Nosler 180gr Partitions. I shot many wolves at 500 plus yards running. I missed a few too. I have hit standing wolves at 600 yards. I shoot red foxes at 300 and 400 yards. I have shot Caribou out to 500 yards, and one Moose at that range. Last year I shot a real nice Caribou at 200 yards, using the 165gr bullet. I also shot a Moose at 250 yards with the Nosler bullet. I hit the Moose right between the eyes, it dropped instantly. The only thing I don't like carrying it for is Grizzly/Brown Bears. Many have been killed by the 30-06, but I still perfer a .338 for them.
My Handi 30-06 has out lived three scopes, and really taken a beating. I carry it strapped to the windshield frame on my Dune Buggy, on the handlebars of my motorcycle, on the rear rack of my snowmachine, or 4-wheeler. The last time I shot it it shot just as good as it always did. unfortionatly, the my 30-06 barrel was stolen three weeks ago. The thieves took it not to get the barrel, but to get the $600.00 scope it was carrying.