I'm a lefty and I'll tell ya it doesn't matter, what does matter is which eye is dominate. I'm left handed but right eyed, so I shoot right not left. On a handi I still don't think it will matter much tho. Lefty's are pretty good at adapting, we have had to ALL our life. One of my greatest childhood accomplishments was learning how to use a spinning reel right handed. You right handers need to try using a left hand one just for fun. There were a lot of hooks in trees and on the opposite bank and alot of backlashes but finally I got there, and now can use either one. Tell your girls good luck. My oldest daughter is a lefty and shoots competition .22 @ 30 yds and 12g Skeet. Good luck and most of all HAVE FUN!