Now, I don't have this caliber in a Handi, but have owned 4-5 22-250's and loaded for twice that many thru the years. I haven't seen one that wouldn't shoot a 52-53Gr bullet, match primer charged with 38grs of H380 powder. (I do not normally offer load data, as mistakes and miss quotes happen and I wouldn't want anyone to be hurt form my mistakes, BUT this H380 powder was DEVELOPED for the 22-250 and the name IS the best loading for it!!) As always, load 10% below and work up in your rifle. But I'll wiling to bet, you will find its good in yours as well.
CW