A friend of mine has used the 300 grain TSX bullet in his Marlin Guide Gun on a coyote
and a couple of hogs. What can I tell you, they all died.......
Accuracy was very good for him at 100 yards, no more than 1.5 inch group as I recall.
I have also used a .45-70 on hogs and deer, but I think the TSX bullet is not needed as
much in this cartridge as it is in smaller calibers / cartridges.