I just went and tried some bullseye in a 45-70 trapdoor carbine with a 20 inch barrel. I used as cast (.459) 450 grain bullets, started at 3.0 grains, not loud, but definitely not quiet enough. Tried 2.0 gr, still too loud. Last try was 1.3 grains - not very loud, and the bullet went through a 2X6. I was going to keep going down on the powder charge, but it got dark.
Last month I was playing with a 300-221 with a 16 in barrel, trying to get quiet loads. I was using 110 grain cast bullets. Started at 3 grains of bullseye, kept going down and finally stopped at 1.2 grain. It was about like an air rifle, and the bullet went through the 2X6 target.