IMR 4227 is mostly used in handguns; but also in small capacity rifle cartridges too. It's burn rate is similar to H 4227, but as always, you need to work up a load, just like switching lots of the same powder. It's burn rate is a bit slower than H 110 and W296, but faster than AA 1680. It is listed for most magnum handgun loads and, like I said, small capacity rifle cases. The 222 Remington case capacity is getting a little large for this powder. Look for the 221 Fireball, 218 Bee, 22 Hornet and 22K Hornet to shoot well with IMR 4227 - not necessarily the fastest, but people have gotten good accuracy with it. It has been used successfully in large straight walled cases such as trap door 45-70 Gov loads too. Good Luck and Good Shooting