Grouch
I see your question, but it's still more important to find your accurate powder/bullet combination load(s) than to mess with seating depth. You are right, seating depth changes with the oglive of the bullet, some are more abruptly curved than others, and will contact the rifling sooner. Chambers are also not all identical, they are made accurately to speck, but there are variations.
To find your chamber length, take an unprimed cartridge case, inside lube the neck, place a bullet just barely into the case, and place this case in the chamber. In a break open, simply slowly and easily push this case in until fully chambered. (You don't want the bullet to stick in the bore.) Take it out and measure the length of the round and you have the rifling contact point. You can then adjust your seating back from this point as much or as little as you want.
Let me again say that this comes after you find the load(s) that are most accurate in your chamber/barrel combination. There's no point tweaking something that won't be satisfactory no matter how much you tweak it.
If you are going to go as far as adjusting seating depth, and in a single shot, you may as well index your rounds as well, making sure that the case is always placed in the chamber and reloading die in the same manner each time. Simply file a nick on the rim and you have a reference point.