I used a Barnes 250 gr. MZ sabot with 80 grs. of 2F in my old 50 cal. TC Scout muzzleloader, which was 1:20.
Seems the longer bullet worked better than shorter ones. IMO the shorter bullets were stripping if you pushed them too fast. I liked that bullet very much, had a good stockpile I got on sale. They were devastating on deer.
Decided to sell it and bought a TC Triumph, couldn't begin to get the MZ down the barrel. Gave them to someone on the forum.
Now shooting Hornady 250 Gr. SST's with 80 grs. BH209.
The Barnes MZ's are a little pricey but work well in a 1:20 twist IMHO.
Hope this helps, TC