It depends on what's out there. Griz? Cougars? Black bear? Angry coons? Rabid squirrels? Unless you are in danger of running across big, nasty, brownies a .357 (loaded properly) will handle most anything. I just feel better with something that starts with a 4. No griz in my neighborhood, so I like to have my .41 with me loaded with 240-gr. Platinum Tips. They're extremely accurate in my model 57, and are plenty powerful enough to handle anything I'm gonna meet. But a .44 Special will do the job as well. Now if I ever do run across a griz, I'm gonna wish I had an AA-12 . . .