powhs: someone very recently ran a comparison test of new bullets, on hogs, but although giving the impression the hogs had been hunted with handguns in those calibers using those particular bullets (new products), the article admitted the bullets/shots were used as 'finishers' to the skull. Although the lsugs used appeared to have expanded nicely, I sort of got the impression there were a bunch of penned hogs that got capped one at a time, in the head, to test the expansion of these slugs. Regardless of caliber I prefer a hardcast flatnosed slug for hunting and penetration.
Realistically you are not going to get 1k'/sec from a 4.25" 45 acp with a 225-230 gn cast slug. You might be able to push it to about 950 but none the less, as a hardcast slug it should function well as a 'finishing shot' for larger hog.
As for that mad sow - if you have to drop your rifle and climb up a tree real quick to get away from one then it sounds like you're on a good hunt, (Gar!) and from the safety of a tree branch a hardcast 45 slug to the brainpan should be adquate for bacon makin'....... just a thought.....