The grip frames on the Blackhawk and Vaquaro are the same, so I'm sure he's not refering to that. As for the frame itself, yes they could be swapped, but you might better trade guns. You would want the barrel also so the front sight would match. Then the innards, while Ruger does a good job on making most things fit, would still likely have to be 'timed' and that could be a major hassel. As I said, better to trade guns... 44 Man