My LCP has worked fine so far in my big hands, but I do find my thumb hitting the mag release. I had the same problem with my KEL-TEK .32 auto, and actually dropped the magazine several times. I took a Dremel Tool to the release button and ground it just about flush. Now to drop a magazine I have to actually push the button in with my thumb nail. Not fast, but a compromise. If I am carrying for real, its a Glock or a 1911.
Larry