i have a 22-250 barrel on my T/C and man that raskle shoots really well.just off a sandbag on the hood of my truck and me standing ,i hit a one inch dot 4 out of 5 shots.the flyer was my fault..i'd say the 243 barrel would be good too. i have a rem 700 in 243 and i shoot 100 gr,partition,,80 gr,ballistic tips by nosler and 58 gr, vmax by hornady and get good results with all. the twist rate in the 22-250 is 1:12 ,,don't know about the 243 but T/C will tell you if you call their toll free line and ask