I have a Glock model 21-SF (45acp) and it shoots rather well using hardball 230 grn. ammo!
It shot well under 4 inches at 20 yards the other day breaking it in for the first time. I have used both Blazer and UMC ammo for this chore. Now hitting "song dogs" at 50 yards with a pistol bullet in the vitals from a Glock 45 acp is asking a lot. I would have no problem using my Glock model 20 (10mm) but then again, if I were hunting with a pistol for coyotes, I would use either my model 29 .44 mag or my model .460 just in case the yardage became expanded futher than 50 yards.