Case separation has more to do with repeated use than load quantities. Every time a case is resized or run through the die, it stretches and there is a thinning of the wall of the case. Sometimes the dies will leave a "separation line" around them, sometimes not, but they are still being thinned as they are used and resized.
My reloadable mosin brass is good for about 3 cycles before I have to do case trimming, etc. but should be checked after every firing for length. If the press is leaving a "thinning ring" around the case, they need to be examined to see if there is simply a mark around the case, or a "dimple" where the brass is separating.
Remember that a bullet is nothing more than a controlled explosion inside a mechanical chamber designed to push the results out the barrel, and when it occurs in the wrong place, all kinds of bad stuff can happen. Reloaders need to be aware of their "use count" for brass, and not assume that it is safe just because it's still shiny. The bigger the caliber, the more violent the results of case failures, so keep your brain in while you reload calibers like .300 Win Mag, etc. You can get into some powder loads that will take the top of your head off if you have a mechanical failure.