Lot of good experience here. I own semi's, levers, bolts, and pumps. My pump carbine in 3006 is my "go-to" rifle for most hunts. I just like the effectiveness of the caliber in a short rifle.
The OP asked what would be my self defense gun should the grabbers outlaw semi's. If that doomsday scenario played out I would choose a lever, Win 92, in either 357 or 44 mag. For self defense, 10 rounds of either caliber in the tube and my matched caliber DA revolver will suit me fine. I live in the suburbs and self defense will be against two legged varmints/predators.
Come to think of it if I lived more rural either wouldn't be a bad choice, as they both are effective on 4 legged critters as well.