Well if you neck down a 243 to a .22 cal, you then have a 22-250. Here's another twist on the whole .22 caliber synerio. A 45 grain hollow point tracels out a 22-250 at 4,000 fps. Best damn varmit gun around.
Enter the .223 aka 5.56 with barrel twists of 1/9, 1/8, and 1/7 that can shoot bullets up to 80 grains. Remeber that much of the variations depend also on barrel length. The issue with heavier bullets in the 22-250 is the 1/14 twist which is standard in most 22/250s.
So here's the solution, Build a 22-250 with a 1/8 twist barrel, 24 inch long and send 72 grain match grade loads at 4,000 fps. Want to have more fun, build it on an A-10 frame and have the hottest shooting .22 cal black gun around. A .22 WSSM is like a .223 on wheeties, a 22-250 built on the same platform with a long 1/8 twist barrel sending rounds out at over 4,000 fps would be like the 22wssm on super steroids.
Oh, and everything you need to load rounds are standard supplies, cases, bullets, etc. Although you may want to experiment with magnum primers to keep them hot, really hot.
Barrel life? Should be longer than a 22-06 by a lot.